Study of US-ATG-F to Prevent Chronic Graft Versus Host Disease (GVHD)

PHASE3CompletedINTERVENTIONAL
Enrollment

260

Participants

Timeline

Start Date

October 10, 2011

Primary Completion Date

October 15, 2015

Study Completion Date

October 15, 2015

Conditions
GVHDAdult Acute Myeloid LeukemiaAdult Acute Lymphoid LeukemiaMyelodysplastic Syndrome
Interventions
BIOLOGICAL

US-ATG-F

20 mg/kg body weight per day, diluted in 250 mL normal saline, IV infusion over 6-16 hours 3 days prior to transplantation

BIOLOGICAL

Placebo

250 mL normal saline, IV infusion over 6-16 hours 3 days prior to transplantation

Trial Locations (28)

5000

Royal Adelaide Hospital, Adelaide

10065

Weill Cornell Medical Center, New York

17033

Penn State Hershey Cancer Institute, Hershey

19104

Abramson Cancer Center of the University at Perlman Center for Advanced Medicine, Philadelphia

27599

University of North Carolina Hospitals, Chapel Hill

27710

Duke University Medical Center, Durham

32610

University of Florida Shands Cancer Center, Gainesville

33612

Moffitt Cancer Center, Tampa

37232

Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville

55905

Mayo Clinic, Rochester

60153

Loyola University Medical Center, Maywood

60637

University of Chicago Medical Center, Chicago

63110

Washington University Medical Center, St Louis

66205

University of Kansas Medical Center, Westwood

70112

Tulane University Health Sciences Center, New Orleans

73104

University of Oklahoma Health Sciences Center, Oklahoma City

75390

University of Texas Southwestern Medical Center, Dallas

78229

Texas Transplant Physician's Group, San Antonio

84132

University of Utah School of Medicine, Salt Lake City

91019

City of Hope, Duarte

94305

Stanford University Medical Center, BMT, Stanford

97239

Oregon Health and Science University, Portland

98108

VA Puget Sound Healthcare System, Seattle

98109

Fred Hutchinson Cancer Research Center, Seattle

02215

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

Massachusetts General Hospital, Boston

03050

Royal Melbourne Hospital, Parkville

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Neovii Biotech

INDUSTRY

NCT01295710 - Study of US-ATG-F to Prevent Chronic Graft Versus Host Disease (GVHD) | Biotech Hunter | Biotech Hunter