Amgen 386 for Recurrent Glioblastoma

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

December 31, 2010

Primary Completion Date

July 31, 2015

Study Completion Date

January 31, 2017

Conditions
Glioblastoma Multiforme
Interventions
DRUG

Amgen 386

"For Cohort A, AMG 386 will be administered intravenously at 30 mg/kg every week.~For Cohort B Phase I, AMG 386 will be administered intravenously at beginning at starting dose level of 15 mg/kg every week.~For Cohort B Phase II, AMG 386 will be administered intravenously at the maximum tolerated dose determined in the Phase I portion of the study every week."

DRUG

Bevacizumab

The dose of bevacizumab will be 10 mg/kg and will be administered intravenously every other week.

Trial Locations (6)

10032

New York - Presbyterian/Columbia University Medical Center, New York

22908

University of Virginia, Charlottesville

90095

University of California Los Angeles, Los Angeles

02114

Massachusetts General Hosptial, Boston

02115

Dana-Farber Cancer Institute, Boston

01655

University of Massachusetts, Worcester, Worcester

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Amgen

INDUSTRY

lead

Dana-Farber Cancer Institute

OTHER