Study of Apremilast to Evaluate the Safety and Effectiveness for Patients With Rheumatoid Arthritis

PHASE2TerminatedINTERVENTIONAL
Enrollment

237

Participants

Timeline

Start Date

December 9, 2010

Primary Completion Date

February 21, 2012

Study Completion Date

September 10, 2012

Conditions
Rheumatoid Arthritis
Interventions
DRUG

Apremilast 30 mg

30 mg oral Apremilast tablets administered twice daily (BID) for 24 weeks during the placebo-controlled phase followed by 30mg Apremilast tablets administered BID for up to 1.5 years in the active treatment / active treatment extension phase.

DRUG

Apremilast 20 mg

20 mg oral Apremilast tablets administered twice daily (BID) for 24 weeks during the placebo-controlled phase followed by 20mg Apremilast tablets administered BID for up to 1.5 years in the active treatment / active treatment extension phase.

DRUG

Placebo

Oral Placebo tablets administered twice daily (BID) for 24 weeks during the placebo-controlled phase followed by 20mg Apremilast tablets administered BID for up to 1.5 years in active treatment / active treatment extension phase. Participants who are nonresponders will advance early to 20 mg Apremilast BID at Week 16.

Trial Locations (50)

15006

Hospital Universitario a Coruña, A Coruña

15706

Hospital Clinico Universitario de Santiago, Santiago de Compostela

16635

Altoona Center for Clinical Research, Duncansville

23185

Center for Excellence in Aging and Geriatric Health, Williamsburg

27834

Physician's East, Greenville

32962

Alastair Kennedy, MD, Vero Beach

33015

San Marcus Research Clinic, Miami

33166

In Vivo Clinical Research, Doral

33175

Advanced Pharma CR, LLC, Miami

33614

Tampa Medical Group, PA, Tampa

34102

Jeffrey Alper, MD Research, Naples

34652

Suncoast Clinical Research, New Port Richey

38320

Hospital Universitario de Canarias, San Cristóbal de La Laguna

39300

Hospital Sierrallana, Torrelavega

44143

David R. Mandel, M.D., Inc., Mayfield

46360

LaPorte County Institute for Clinical Research, Inc., Michigan City

49015

Associated Internal Medicine Specialists, PC, Battle Creek

55121

Saint Paul Rheumatology, Eagan

73103

Health Research of Oklahoma, Oklahoma City

75231

Metroplex Research Center, Dallas

Modern Research Associates, Dallas

78215

Sun Research Institute, San Antonio

78232

Stone Oak Rheumatology, San Antonio

78759

Austin Regional Clinic, Austin

80230

Denver Arthritis Clinic, Denver

85023

Arizona Research Center, Phoenix

85234

ArthroCare, Arthritis Care Research, Gilbert

91786

Inland Rheumatology Clinical Trials, Inc., Upland

91942

TriWest Research Associates, La Mesa

92260

Desert Medical Advances, Palm Desert

94304

Stanford University Medical Center, Palo Alto

95661

Med Investigations/Sierra, Roseville

99204

Arthritis Northwest, Rheumatology, Spokane

638 00

Revmatologie s.r.o., Brno

748 01

L.K.N. Arthrocentrum s.r.o., Hlučín

253 01

ARTMEDI UPD s.r.o., Hostivice

128 50

Revmatologicky ustav, Prague

140 00

Revmatologicka ambulance, Prague

140 59

Fakultni Thomayerova nemocnice s poliklinikou, Prague

760 01

PV - MEDICAL, s.r.o., Zlín

15-351

NZOZ Osteo-Medic s.c. Artur Racewicz, Jerzy Supronik, Bialystok

15-461

NZOZ Centrum Osteoporozy i Chorob Kostno-Stawowych, Bialystok

85-168

Szpital Uniwersytecki nr 2 im. Dr Jana Biziela w Bydgoszczy, Bydgoszcz

82-300

Centrum Kliniczno-Badawcze, Elblag

81-384

Centrum Leczenia Chorob Cywilizacyjnych, Gdynia

40-478

Centrum Leczenia Chorob Cywilizacyjnych, Katowice

30-552

Malopolskie Centrum Medyczne (408), Krakow

20-607

Niepubliczny Zaklad Opieki Zdrowotnej REUMED, Lublin

61-397

Prywatna Praktyka Lekarska Pawel Hrycaj, Poznan

02-777

Centrum Leczenia Chorob Cywilizacyjnych, Warsaw

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY