584
Participants
Start Date
January 9, 2012
Primary Completion Date
July 31, 2016
Study Completion Date
August 31, 2016
Inactive Substance
Inactive Substance will be given in a double-blind fashion for 20 full days. The treatment course includes a bolus dose on the day of randomization, 7 days of full dose (40 mg/day), 7 days of half dose (20 mg/day), and 6 days of tapering doses (12 mg/day and 4 mg/day).
Methylprednisolone
Methylprednisolone will be given in a double-blind fashion for 20 full days. The treatment course includes a bolus dose on the day of randomization, 7 days of full dose (40 mg/day), 7 days of half dose (20 mg/day), and 6 days of tapering doses (12 mg/day and 4 mg/day).
Syracuse VA Medical Center, Syracuse, NY, Syracuse
VA Western New York Healthcare System, Buffalo, NY, Buffalo
VA Pittsburgh Healthcare System University Drive Division, Pittsburgh, PA, Pittsburgh
Salem VA Medical Center, Salem, VA, Salem
Asheville VA Medical Center, Asheville, NC, Asheville
Wm. Jennings Bryan Dorn VA Medical Center, Columbia SC, Columbia
Atlanta VA Medical and Rehab Center, Decatur, Decatur
North Florida/South Georgia Veterans Health System, Gainesville, FL, Gainesville
Miami VA Healthcare System, Miami, FL, Miami
Bay Pines VA Healthcare System, Pay Pines, FL, Bay Pines
Memphis VA Medical Center, Memphis, TN, Memphis
Robley Rex VA Medical Center, Louisville, KY, Louisville
Louis Stokes VA Medical Center, Cleveland, OH, Cleveland
Cincinnati VA Medical Center, Cincinnati, OH, Cincinnati
Minneapolis VA Health Care System, Minneapolis, MN, Minneapolis
Oklahoma City VA Medical Center, Oklahoma City, OK, Oklahoma City
Michael E. DeBakey VA Medical Center, Houston, TX, Houston
South Texas Health Care System, San Antonio, TX, San Antonio
VA Salt Lake City Health Care System, Salt Lake City, UT, Salt Lake City
Phoenix VA Health Care System Carl T. Hayden VA Medical Center, Phoenix, AZ, Phoenix
VA Sierra Nevada Health Care System, Reno, NV, Reno
VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles
VA Long Beach Healthcare System, Long Beach, CA, Long Beach
VA San Diego Healthcare System, San Diego, CA, San Diego
VA Loma Linda Healthcare System, Loma Linda, CA, Loma Linda
VA Palo Alto Health Care System, Palo Alto, CA, Palo Alto
Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis
Omaha VA Nebraska-Western Iowa Health Care System, Omaha, NE, Omaha
Clement J. Zablocki VA Medical Center, Milwaukee, WI, Milwaukee
VA Caribbean Healthcare System, San Juan, PR, San Juan
VA Office of Research and Development
FED