Prevention of Cardiac Allograft Vasculopathy Using Rituximab (Rituxan) Therapy in Cardiac Transplantation

PHASE2TerminatedINTERVENTIONAL
Enrollment

362

Participants

Timeline

Start Date

September 30, 2011

Primary Completion Date

October 31, 2015

Study Completion Date

October 31, 2015

Conditions
Cardiac Allograft VasculopathyHeart Transplant Recipients
Interventions
BIOLOGICAL

Rituximab induction/conventional immunosuppression (tacrolimus, MMF, and steroid taper)

DRUG

Rituximab placebo/conventional immunosuppression (tacrolimus, MMF, and steroid taper)

Trial Locations (24)

10029

Mount Sinai School of Medicine, New York

15212

Allegheny General Hospital, Pittsburgh

19102

Drexel University College of Medicine, Philadelphia

19104

University of Pennsylvania, Philadelphia

21201

University of Maryland, Baltimore

29425

Medical University of South Carolina, Charleston

44195

Cleveland Clinic Foundation, Cleveland

53792

University of Wisconsin, Madison

55407

Minneapolis Heart Institute, Minneapolis

55455

University of Minnesota, Minneapolis

60611

Northwestern University, Chicago

75230

Medical City Dallas Hospital/CRSTI, Dallas

77030

The Methodist Hospital, Houston

84157

Intermountain Medical Center, Murray

90095

Ronald Regan UCLA Medical Center, Los Angeles

90211

Cedars Sinai Heart Institute, Beverly Hills

94304

Stanford University/Palo Alto VA, Palo Alto

94305

Stanford University, Stanford

94143-0124

University of California San Francisco, San Francisco

02111

Tufts Medical Center, Boston

02114

Massachusetts General Hospital, Boston

02115

Brigham and Women's Hospital, Boston

10032'

Columbia University Medical Center, New York

84132-2401

University of Utah, Salt Lake City

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

collaborator

Clinical Trials in Organ Transplantation

NETWORK

collaborator

Genentech, Inc.

INDUSTRY

collaborator

Rho Federal Systems Division, Inc.

INDUSTRY

lead

National Institute of Allergy and Infectious Diseases (NIAID)

NIH