A Double-Blind Study to Evaluate the Efficacy and Safety of BMN 110 in Patients With Mucopolysaccharidosis IVA (Morquio A Syndrome)

PHASE3CompletedINTERVENTIONAL
Enrollment

177

Participants

Timeline

Start Date

February 28, 2011

Primary Completion Date

August 31, 2012

Study Completion Date

August 31, 2012

Conditions
MPS IV A
Interventions
DRUG

BMN 110 Weekly

BMN 110 Weekly: Intravenous infusion of BMN 110 at a dose of 2.0 mg/kg administered over a period of approximately 4 hours once a week.

DRUG

Placebo

Intravenous infusion of placebo solution at a volume equivalent to that needed for 2.0 mg/kg dose of BMN 110 administered over a period of approximately 4 hours once a week.

DRUG

BMN 110 Every Other Week

BMN 110 Every Other Week: Intravenous infusion of BMN 110 at a dose of 2.0 mg/kg administered over a period of approximately 4 hours every other week and infusions of placebo on alternating weeks.

Trial Locations (28)

Unknown

Oakland

Wilmington

Washington D.C.

Chicago

New York

Seattle

Córdoba

Campina Grande

Porto Alegre

Montreal

Sherbrooke

Toronto

Bogotá

Copenhagen

Lyon

Paris

Mainz

Monza

Tokyo

Amsterdam

Coimbra

Doha

Riyadh

Seoul

Taipei

Birmingham

London

Manchester

Sponsors
All Listed Sponsors
lead

BioMarin Pharmaceutical

INDUSTRY