LUX-Breast 2; Afatinib in HER2 (Human Epidermal Growth Factor Receptor)-Treatment Failures

PHASE2CompletedINTERVENTIONAL
Enrollment

74

Participants

Timeline

Start Date

May 24, 2011

Primary Completion Date

March 13, 2017

Study Completion Date

March 13, 2017

Conditions
Breast Neoplasms
Interventions
DRUG

Vinorelbine 25 mg/m2 weekly

Patients to additionally receive vinorelbine at a dose of 25 mg/m2 weekly on disease progression on afatinib monotherapy

DRUG

Afatinib 40mg once daily (OD)

Patient to receive afatinib monotherapy at a dose of 40 mg/d until progression of their disease

DRUG

Paclitaxel 80 mg/m2 weekly

Patients to additionally receive paclitaxel at a dose of 80 mg/m2 weekly on disease progression on afatinib monotherapy

Trial Locations (27)

100

National Taiwan University Hospital, Taipei

112

Koo Foundation Sun Yet-Sen Cancer Center, Taipei

Taipe Veterans General Hospital, Taipei

404

China Medical University Hospital, Taichung

10449

Mackay Memorial Hospital, Taipei

40705

Taichung Veterans General Hospital, Taichung

129128

N.A. Semashko Central Clinical Hospital, Moscow, Moscow

350040

Clinical Oncology Dispensary No. 1, Dept. Chemotherapy, Krasnodar

354057

"GUZ Oncological Dispesary #2", Sochi

357502

"SBIH of Stavropol territory Pyatigorsk Oncol. Dispensary", Pyatigorsk

411001

Ruby Hall Clinic, Pune

420029

"St.Auton.Heal.Inst.Rep.Clin.Onc.Disp.of MoH of Rep. Tatarstan", Kazan'

440010

Central India Cancer Research Institute, Nagpur

444606

Sujan Surgical Cancer Hospital, Amravati

Unknown

Queen Mary Hospital, Hong Kong

Prince of Wales Hospital, Shatin

400 012

Tata Memorial Hospital, Maharashtra

422 004

Curie Manavata Cancer Centre, Maharashtra

695 011

Regional Cancer Center, Thiruvananthapuram

80-211

University Clinical Center, Gdansk, Gdansk

443 031

"SBIH Samara Regional Clinical Oncol. Dispensary, Samara", Samara

355 047

Stavropol Regional Clin. Oncology Dispensary Dept. Oncology, Stavropol

150 040

Yaroslavl Regional Clinical Oncology Hosp. Dept.Chemotherapy, Yaroslavl

EX31 4JB

North Devon District Hospital, Barnstaple

BH7 7DW

Royal Bournemouth and Christchurch Hospital, Bournemouth

EX2 5DW

Royal Devon and Exeter Hospital, Exeter

W6 8RF

Charing Cross Hospital, London

Sponsors
All Listed Sponsors
lead

Boehringer Ingelheim

INDUSTRY

NCT01271725 - LUX-Breast 2; Afatinib in HER2 (Human Epidermal Growth Factor Receptor)-Treatment Failures | Biotech Hunter | Biotech Hunter