Pasireotide & Everolimus in Adult Patients With Radioiodine-Refractory Differentiated & Medullary Thyroid Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

November 30, 2010

Primary Completion Date

February 28, 2019

Study Completion Date

February 28, 2019

Conditions
Thyroid Cancer
Interventions
DRUG

Everolimus

Everolimus 10 mg daily continuously (switch to 2-drug combination at progression if no intolerable toxicity)

DRUG

Pasireotide

Pasireotide 1200 mcg bid for 4 weeks followed by Pasireotide long acting release (LAR) 60 mg i.m. once every 4 weeks

DRUG

Everolimus and Pasireotide

Everolimus 10 mg daily continuously together with Pasireotide 1200 mcg bid for 4 weeks followed by Pasireotide long acting release (LAR) 60 mg i.m. once every 4 weeks

Trial Locations (3)

15232

University of Pittsburgh Cancer Institute, Pittsburgh

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Winship Cancer Institute, Atlanta

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

lead

Emory University

OTHER