A Study Inhibiting Telomerase to Reverse Trastuzumab Resistance in HER2+ Breast Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

January 31, 2011

Primary Completion Date

August 31, 2012

Study Completion Date

October 31, 2015

Conditions
Breast Neoplasms
Interventions
DRUG

GRN163L in combination with trastuzumab

GRN163L will be administered in escalating dose cohorts on Day 1 of each 21-day cycle prior to trastuzumab infusion. Trastuzumab will be a administered day 1 of each 21-day cycle after GRN163L. There will be a 30 minute observation period between the end of the GRN163L infusion and the beginning of the trastuzumab infusion.

Trial Locations (1)

46202

Indiana University Simon Cancer Center, Indianapolis

All Listed Sponsors
collaborator

Breast Cancer Research Foundation

OTHER

collaborator

Geron Corporation

INDUSTRY

lead

Indiana University

OTHER

NCT01265927 - A Study Inhibiting Telomerase to Reverse Trastuzumab Resistance in HER2+ Breast Cancer | Biotech Hunter | Biotech Hunter