A Study of MabThera/Rituxan (Rituximab) in Combination With Fludarabine And Cyclophosphamide as Primary Therapy in Elderly Patients With Chronic Lymphocytic Leukemia

PHASE2CompletedINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

July 17, 2011

Primary Completion Date

April 3, 2017

Study Completion Date

April 3, 2017

Conditions
Lymphocytic Leukemia, Chronic
Interventions
DRUG

Cyclophosphamide

150 milligrams per square meter (mg/m\^2) intravenously (IV) on Days 1-3 of each 28-day cycle for 6 cycles

DRUG

Fludarabine

12.5 mg/m\^2 IV on Days 1-3 of every 28-day cycle for 6 cycles

DRUG

Rituximab

375 mg/m\^2 IV Day 0 of Cycle 1, 500 mg/m\^2 IV Day 1 of Cycles 2-6. Each cycle was 28 days.

Trial Locations (12)

18101

Haemek Medical Center; Hematology Department, Afula

22100

Western Galilee Hospital - Nahariya, Nahariya

44281

Meir Medical Center; Internal Dept A, Kfar Saba

49100

Beilinson Medical Center; Haematology, Petah Tikva

70300

ASSAF Harofe; Department of Hematology, Rishon LeZiyyon

3109601

Rambam Medical Center; Heamatology & Bone Marrow Transplantation, Haifa

3339419

Bnei-Zion Medical Center; Hematology Dept, Haifa

6423906

Ichilov Sourasky Medical Center; Heamatology, Tel Aviv

7661041

Kaplan Medical Center, Rehovot

8410101

Soroka Medical Center; Hematology Deptartment, Beersheba

9103102

Shaare Zedek Medical Center; Hematology Dept., Jerusalem

9112001

Hadassah Ein Karem Hospital; Haematology, Jerusalem

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY

NCT01263704 - A Study of MabThera/Rituxan (Rituximab) in Combination With Fludarabine And Cyclophosphamide as Primary Therapy in Elderly Patients With Chronic Lymphocytic Leukemia | Biotech Hunter | Biotech Hunter