Tivantinib Plus Erlotinib Versus Placebo Plus Erlotinib for the Treatment of Non-squamous, Non-small-cell Lung Cancer

PHASE3TerminatedINTERVENTIONAL
Enrollment

1,048

Participants

Timeline

Start Date

January 11, 2011

Primary Completion Date

December 15, 2012

Study Completion Date

December 15, 2012

Conditions
Non Squamous, Non-small-cell Lung Cancer
Interventions
DRUG

Tivantinib

Tivantinib 720 mg daily as 3 x 120 mg oral tablets given twice a day

DRUG

Placebo

Tivantinib Placebo tablets given twice a day

DRUG

Erlotinib

Erlotinib 150 mg oral tablets, given once a day

Trial Locations (304)

9

Grenoble

27

Lima

34

Lima

41

Lima

2065

St Leonards

2570

Duffel

2930

Brasschaat

4120

Greenslopes

4700

Næstved

5020

Salzburg

5707

Helmond

7513

Enschede

10032

New York

10043

Orbassano

10117

Berlin

10467

The Bronx

10924

Goshen

12100

Cuneo

12203

Berlin

12808

Prague

14033

Caen

14263

Buffalo

15006

A Coruña

15009

A Coruña

15706

Santiago de Compostela

17109

Harrisburg

19104

Philadelphia

19713

Newark

20089

Rozzano

20155

Gainesville

20162

Milan

20176

Leesburg

20900

Monza

21075

Hamburg

21204

Towson

22031

Fairfax

22191

Woodbridge

22205

Arlington

22601

Winchester

22927

Großhansdorf

23035

Sondalo

23112

Midlothian

23298

Richmond

25000

Besançon

26100

Cremona

28034

Madrid

28041

Madrid

28100

Novara

29010

Málaga

29120

Columbia

29307

Spartanburg

29601

Greenville

29605

Greenville

29609

Brest

29615

Greenville

29640

Easley

30060

Marietta

30106

Austell

30117

Carrollton

30121

Cartersville

30134

Douglasville

30341

Atlanta

30625

Hanover

31059

Toulouse

31302

Krakow

Olsztyn

32457

Porta Westfalica

32504

Pensacola

33006

Oviedo

33012

Miami Beach

33081

Aviano

33916

Fort Myers

34125

Kassel

35033

Rennes

35128

Padua

35922

Rzeszów

36204

Vigo

37044

Tours

37203

Nashville

37404

Chattanooga

37909

Knoxville

38104

Memphis

38138

Bartlett

Germantown

38320

San Cristóbal de La Laguna

38671

Southaven

39800

Rancho Mirage

41013

Seville

41124

Modena

41700

Seville

43126

Parma

44195

Cleveland

44280

Guadalajara

45122

Essen

45242

Cincinnati

46010

Valencia

46032

Carmel

46037

Fishers

46140

Greenfield

46219

Indianapolis

46227

Indianapolis

46526

Goshen

48202

Indianapolis

48431

Rheine

48903

Barakaldo

50009

Zaragoza

50134

Florence

51109

Cologne

51375

Leverkusen

53203

Pardubice

55131

Mainz

55455

Minneapolis

57100

Livorno

59037

Lille

60637

Chicago

63110

St Louis

64460

Monterrey

68000

Oaxaca City

68167

Mannheim

68198

Omaha

68803

Grand Island

69495

Pierre-Bénite

70000

Oaxaca City

70124

Bari

70384

Ostrava

70891

Szczecin

73730

Esslingen am Neckar

74245

Löwenstein

75013

Paris

75230

Paris

75246

Dallas

76104

Fort Worth

76132

Fort Worth

76137

Karlsruhe

78050

Villingen-Schwenningen

78640

Kyle

78665

Round Rock

78666

San Marcos

78681

Round Rock

78705

Austin

78731

Austin

Cedar Park

78745

Austin

78758

Austin

80012

Aurora

80120

Littleton

80124

Lone Tree

80131

Napoli

80138

Parker

80218

Denver

80220

Denver

80228

Lakewood

80260

Thornton

80303

Boulder

80336

München

80501

Longmont

80907

Colorado Springs

80909

Colorado Springs

81925

München

82131

Gauting

82550

Prabuty

83100

Avellino

84112

Salt Lake City

85704

Tucson

85710

Tucson

85715

Tucson

87131

Albuquerque

89052

Henderson

89074

Henderson

89128

Las Vegas

89148

Las Vegas

89169

Las Vegas

89202

Joinville

90048

Los Angeles

90146

Palermo

90404

Santa Monica

92270

Rancho Mirage

94805

Villejuif

95126

Catania

97062

Tualatin

97213

Portland

97225

Portland

97227

Portland

97239

Portland

97401

Eugene

97477

Springfield

98104

Seattle

98684

Vancouver

98686

Vancouver

98902

Yakima

99437

Bad Berka

115478

Moscow

125367

Moscow

197022

Saint Petersburg

197758

Saint Petersburg

198255

Saint Petersburg

200385

Craiova

300040

Tula

305035

Kursk

357502

Pyatigorsk

400015

Cluj-Napoca

410167

Oradea

426009

Izhevsk

454087

Chelyabinsk

603081

Veliky Novgorod

625041

Tyumen

664035

Irkutsk

7500710

Santiago

7500921

Santiago

7520378

Santiago

8380455

Santiago

89202050

Joinville

85724-5024

Tucson

Unknown

Oxnard

Lexington

Louisville

Latham

Kettering

Buenos Aires

San Miguel de Tucumán

Viedma

Camperdown

Kogarah

Perth

Wollongong

Woodville

Brussels

Ijuí

Porto Alegre

São Paulo

Ústí nad Labem

Marseille

Saint-Priest-en-Jarez

Strasbourg

Erfurt

München

Ancona

Torino

Mexico City

Mexico City

Amsterdam

Arequipa

Lima

Lublin

Opole

Poznan

Torun

Wałbrzych

Novosibirsk

Madrid

Lund

02114

Boston

07018

East Orange

17033-0850

Hershey

75216-9982

Dallas

S2000SDV

Rosario

X5000AA1

Córdoba

A-4600

Wels

41253-190

Salvador

20231-050

Rio de Janeiro

99010-080

Passo Fundo

99010-260

Passo Fundo

90430-090

Porto Alegre

01224-10

São Paulo

T6G 1Z2

Edmonton

V3V 1Z2

Surrey

V8R lC3

Victoria

RSE 0V9

Winnipeg

N6A 4L6

London

P7B6V4

Thunder Bay

M5G 1X5

Toronto

H1T 2M4

Montreal

H2W 1S6

Montreal

G1V 4G5

Québec

M5G 2M9

Toronto

DK-2730

Herlev

DK-5000

Odense

06120

Halle

H-6772

Deszk

H-5703

Gyula

H-3233

Mátraháza

H-8000

Székesfehérvár

H-5000

Szolnok

06132

Perugia

00152

Roma

07100

Sassari

03039

Sora

43-360

Bystra

60-569

Poznan

03010

Alicante

08003

Barcelona

08907

Barcelona

08243

Manresa

07010

Palma de Mallorca

08208

Sabadell

581 85

Linköping

GU2 7XX

Guildford

AB25 2ZN

Aberdeen

G12OYN

Glasgow

NW1 2PG

London

W6 9RF

London

M20 4BX

Manchester

NG5 1PB

Nottingham

S10 2SJ

Sheffield

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)

INDUSTRY

lead

Daiichi Sankyo

INDUSTRY