Efficacy and Safety of CDP6038 in Patients With Rheumatoid Arthritis With an Unsuccessful Response to Anti-Tumor Necrosis Factor (Anti-TNF) Therapy

PHASE2CompletedINTERVENTIONAL
Enrollment

221

Participants

Timeline

Start Date

November 30, 2010

Primary Completion Date

June 30, 2012

Study Completion Date

June 30, 2012

Conditions
Rheumatoid Arthritis
Interventions
BIOLOGICAL

CDP6038

60 mg subcutaneously (sc) at Weeks 0, 2, 4 6, 8, and 10

BIOLOGICAL

CDP6038

120 mg sc at Weeks 0, 2, 4 6, 8, and 10

BIOLOGICAL

CDP6038

240 mg sc at Weeks 0, 2, 4 6, 8, and 10

BIOLOGICAL

Tocilizumab (Actemra or RoActemra)

8 mg/kg intravenously (iv) at Weeks 0, 4 and 8

BIOLOGICAL

CDP6038

60 mg sc at Weeks 0, 4 and 8

BIOLOGICAL

CDP6038

240 mg sc at Weeks 0, 4 and 8

BIOLOGICAL

CDP6038

120 mg sc at Weeks 0, 4 and 8

OTHER

Placebo sc

0.9% Sodium chloride for injection at Weeks 0, 2, 4 6, 8, and 10

OTHER

Placebo sc

0.9% Sodium chloride for injection at Weeks 2, 6 and 10

OTHER

Placebo iv

0.9% Sodium chloride for injection at Weeks 0, 4 and 8

Trial Locations (82)

Unknown

166, Mesa

154, Paradise Valley

118, Scottsdale

103, Hot Springs

125, Jonesboro

127, Covina

148, La Jolla

184, Long Beach

177, Los Angeles

104, Palo Alto

149, Sacramento

158, San Diego

129, Santa Maria

164, Upland

107, Wildomar

141, Hamden

137, Norwalk

101, Trumbull

111, Lewes

176, Aventura

186, Daytona Beach

151, DeBary

114, Jupiter

183, Pinellas Park

178, Sarasota

140, South Miami

157, Tampa

130, Gainesville

162, Newnan

153, Savannah

113, Stockbridge

116, Idaho Falls

160, Moline

156, Rock Island

168, Springfield

133, Cedar Rapids

172, Kansas City

185, Saint Clair Shores

112, St Louis

134, St Louis

102, Lincoln

171, Freehold

163, New Brunswick

152, Toms River

174, Brooklyn

115, Rochester

109, Belmont

170, Charlotte

150, Cincinnati

108, Columbus

100, Dayton

110, Oklahoma City

165, Duncansville

117, Wexford

105, Nashville

106, Nashville

120, Amarillo

135, Austin

128, Dallas

126, Houston

132, Houston

138, Houston

181, Houston

145, Mesquite

143, Nassau Bay

122, San Antonio

144, Tomball

142, Victoria

121, Salt Lake City

139, Chesapeake

119, Seattle

175, Tacoma

136, Beckley

167, Clarksburg

401, Brussels

400, Liège

209, Torquay

201, Wigan

206, Essex

205, London

204, Newcastle upon Tyne

208, Southampton

Sponsors

Lead Sponsor

All Listed Sponsors
lead

UCB Pharma

INDUSTRY