NCT01234532 - Entinostat and Anastrozole in Treating Postmenopausal Women With TNBC That Can Be Removed by Surgery | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

October 31, 2010

Primary Completion Date

May 31, 2017

Study Completion Date

May 31, 2017

Conditions

Estrogen Receptor-negative Breast CancerHER2-negative Breast CancerProgesterone Receptor-negative Breast CancerStage I Breast CancerStage II Breast CancerStage IIIA Breast CancerTriple-negative Breast Cancer

Interventions

DRUG

entinostat

orally

DRUG

anastrozole

Given PO

OTHER

diagnostic laboratory biomarker analysis

"Correlative studies will be performed utilizing tissue and blood. A baseline tumor biopsy is done prior to study entry or archival tissue from diagnosis may be used and a representative tumor sample is submitted at time of surgery.~Bloods are drawn for correlative sciences on day 1 and 15 of treatment prior to entinostat dosing and 30 mins post and again on day of surgery."

PROCEDURE

therapeutic conventional surgery

Lumpectomy or mastectomy will be performed follwoing day 29 of study therapy

Trial Locations (1)

21201

University of Maryland Baltimore, Baltimore