A Study Evaluating the Absorption Of Varenicline Through The Skin Following Once Daily Application Of A Patch For 14 Days

PHASE1CompletedINTERVENTIONAL
Enrollment

45

Participants

Timeline

Start Date

November 30, 2010

Primary Completion Date

March 31, 2011

Study Completion Date

March 31, 2011

Conditions
Smoking Cessation
Interventions
DRUG

varenicline free base patch

varenicline transdermal delivery system (12.0 mg payload \[drug amount loaded in each patch\]) will be applied to the skin once daily for 14 days

DRUG

varenicline free base patch

varenicline transdermal delivery system (18.0 mg payload \[drug amount loaded in each patch\]) will be applied to the skin once daily for 14 days

DRUG

placebo patch

Matched placebo transdermal delivery system will be applied to the skin once daily for 14 days

DRUG

varenicline free base patch

varenicline transdermal delivery system (24.0 mg payload \[drug amount loaded in each patch\]) will be applied to the skin once daily for 14 days

DRUG

placebo patch

Matched placebo transdermal delivery system will be applied to the skin once daily for 14 days

DRUG

varenicline free base patch

2 varenicline transdermal delivery systems (combined to achieve a maximum drug payload of 36 mg) will be applied to the skin, side by side once daily, for 14 days

DRUG

placebo patch

Matched placebo transdermal delivery systems will be applied to the skin, side by side, once daily for 14 days

Trial Locations (1)

58104

Pfizer Investigational Site, Fargo

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY