Safety and Tolerability Study of ISIS EIF4E Rx in Combination With Docetaxel and Prednisone (CRPC)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

113

Participants

Timeline

Start Date

November 30, 2010

Primary Completion Date

May 31, 2013

Study Completion Date

December 31, 2013

Conditions
Castrate-Resistant Prostate Cancer
Interventions
DRUG

ISIS EIF4E Rx

800 mg ISIS EIF4E Rx administered as a 3-hour intravenous infusion on Days 1, 8 and 15 of each 21 day cycle.

DRUG

ISIS EIF4E Rx

1000 mg ISIS EIF4E Rx administered as a 3-hour intravenous infusion on Days 1, 8 and 15 of each 21 day cycle.

DRUG

ISIS EIF4E Rx

(Dose identified in Part 1)ISIS EIF4E Rx administered as a 3-hour intravenous infusion on Days 1, 8 and 15 of each 21 day cycle.

DRUG

Prednisone

5 mg administered orally twice daily on days 1, 8, 15 and 22 of each cycle

DRUG

Docetaxel

75 mg/m2 administered as a 1-hour intravenous infusion on day 1 of each cycle

Trial Locations (38)

1032

Szent Janos Hospital and Unified Hospitals of North Buda, Budapest

1082

Semmelweis University Faculty of Medicine, Budapest

1122

National Institute of Oncology, Budapest

7624

University of Pecs, Institute of Oncology, Pécs

8000

Fejer County St. Gyorgy Hospital, Dept of Oncology, Székesfehérvár

10019

St. Luke's - Roosevelt Hospital Center, New York

14642

James P. Wilmont Cancer Center - University of Rochester Medical Center, Rochester

22328

Fundeni Clinical Institute, Bucharest

33136

University of Miami, Miller School of Medicine - Sylvester Comprehensive Cancer Center, Miami

33805

Lakeland Regional Cancer Center, Lakeland

40503

Central Baptist Hospital Clinical Research Center, Lexington

44718

Gabrail Cancer Center, Canton

50659

"Prof. Dr Th Burghele Clinical Hospital", Bucharest

71103

Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport

72703

Highlands Oncology Group, Fayetteville

80528

Fort Range Cancer Center, Fort Collins

105077

State Medical Institution of the City of Moscow: Municipal Clinical Hospital #57 under Moscow Department for Healthcare, Moscow

129128

Non-State Medical Institution: Central Clinical Hospital #2 n.a. N.A. Semashko under OJSC Russian Railways, Chemotherapy Dpmt, Moscow

197022

St. Petersburg State Medical Institution: St. Petersburg Municipal Oncological Center, Department of Urologic Oncology, Saint Petersburg

197758

Russian Research Center for Radiology and Surgical Technologies, Saint Petersburg

200385

SC Oncolab SRL, Medical Oncology Dept, Craiova

249036

"Federal State Budget Institution: Medical Radiological Research Center under the Ministry of Health Care and Social Development of the Russian Federation", Obninsk

305035

State Medical Institution: Kursk Regional Oncological Center, Chemotherapy Dept, Kursk

400058

SC Medisprof SRL, Cluj-Napoca

430031

Dr Constantin Opris Emergency County Hospital, Baia Mare

454087

State Therapeutical and Prophylactic Institution: Chelyabinsk Regional Clinical Oncology Center, Chemotherapy Department, Chelyabinsk

500366

S.C. Rapid Diagnosis Polyclinic SRL, Brasov

510077

Alba Lulia Emergency County Hospital, Alba Iulia

900635

S.C. Provita 2000 SRL, Constanța

92404-4816

San Bernardino Urological Associates, San Bernardino

06850

Norwalk Hospital- Whittingham Cancer Center, Norwalk

15-027

Ewa Pilecka Clinical Oncology Department and Outpatient Chemotherapy Unit, Bialostockie M.Sklodowska-Curie Oncology Centre in Bialystok, Bialystok

86-300

Regionalny Szpital Specjalistyczny im. dr Wladyslawa Bieganskiego, Oddzial Onkologii Klinicznej, Grudziądz

10-228

Department of Chemotherapy, Health Care Facility of the Ministry of Internal Affairs and Administration and Warminsko-Mazurskie Oncology Centre in Olsztyn, Olsztyn

45-060

Clinical Oncology Department and Day Hospitalization Unit, Independent Public Healthcare Facility T. Koszarowski Opolskie Oncology Centre in Opole, Opole

02-781

Department of Urologic Oncology, Maria Sklodowska-Curie Institute of Oncology, Warsaw

04-125

Clinical Oncology Department/Chemotherapy Department, MAGODENT Non-Public Healthcare Facility, Branch Facility No. 4, Warsaw

00927

Fundacion de Investigacion de Diego, San Juan

Sponsors
All Listed Sponsors
lead

Ionis Pharmaceuticals, Inc.

INDUSTRY