Study to Evaluate Safety and Effectiveness of Oral Apremilast (CC-10004) in Patients With Moderate to Severe Plaque Psoriasis.

PHASE3CompletedINTERVENTIONAL
Enrollment

413

Participants

Timeline

Start Date

November 22, 2010

Primary Completion Date

March 15, 2012

Study Completion Date

November 30, 2016

Conditions
Plaque Psoriasis
Interventions
DRUG

Apremilast

Apremilast 30mg by mouth (PO) twice a day (BID) for 32 weeks

DRUG

Placebo

Identically matching placebo by mouth BID for first 16 weeks. Placebo participants will be switched to receive apremilast 30 mg BID at Week 16-32.

OTHER

Topical or Phototherapy Therapy

Topical therapies such as low-potency or weak corticosteroids or phototherapies such as light therapy are added for non-responders at Week 32, (\< PASI-50) and added to their treatment regimen. The decision to add these treatments during this phase can only be made at the Week 32 visit.

Trial Locations (46)

1090

Medizinische Universitat Wien, Universitatsklinik fur Dermatologie. Abteilung fur Immundermatologie, Vienna

1205

Hopitaux Universitaires de Geneve-HUG, Geneva

2400

Bispebjerg Hospital, Copenhagen

8091

University of Zurich Hospital, Zurich

8916

Hospital Universitari Germans Trias i Pujol, Badalona (Barcelona)

15006

Hospital Abente y Lago, A Coruña

15831

Hautarztpraxis Mahlow, Mahlow

23507

Virginia Medical Research, Norfolk

24105

Universitäts-Hautklinik Kiel, Kiel

25030

Centre d'lnvestigation Clinique, Hopital Jean Minjoz, Besançon

27103

PMG Research of Winston-Salem, Winston-Salem

27104

Wake Forest University Health Sciences, Winston-Salem

28006

Hospital Universitario La Princesa, Madrid

28041

Hospital Universitario 12 de Octubre, Madrid

28922

Hospital Universitario Fundacion Alcorcon, Alcorcón

29560

Radiant Research, Inc., Anderson

30263

MedaPhase Inc., Newnan

30342

Advanced Medical Research, Atlanta

31000

Larrey University Hospital, Toulouse

33136

Florida Academic Dermatology Center, Miami

33604

Hospital haut leveque, Pessac

37126

A.O.U. Integrata di Verona Universitá degli Studi di Verona Sezione di Dermatologia e Venerologia, Verona

60611

Northwestern University Northwestern Medical Faculty Foundation, Chicago

71913

Burke Pharmaceutical Research, Hot Springs

75231

Modern Research Associates PLLC, Dallas

77004

Center for Clinical Studies, Houston

77598

Center for Clinical Studies, Webster

78705

Austin Dermatology Associates, Austin

80131

Universita degli Studi di Napoli Federico II, Napoli

85023

Arizona Skin and Laser Therapy Inst., Ltd., Phoenix

90045

Dermatology Research Associates, Los Angeles

90404

Clinical Science Institute, Santa Monica

93309

Bakersfield Dermatology and Skin Cancer Medical Group, Bakersfield

02111

Tufts Medical Center, Boston

02919

Clinical Partners, LLC, Johnston

T3G 0B4

Northwest Dermatology and Laser Centre, Calgary

T5K 1X3

Stratica Medical, Edmonton

A1C 2H5

NewLab Clinical Research, St. John's

K9J 5K2

Skin Center for Dermatology, Peterborough

N8W 5L7

Windsor Clinical Research Inc., Winsor

J1H 4J6

Q & T Research Sherbrooke Inc., Sherbrooke

G1V 4X7

Centre de Recherche Dermatologique du Quebec Metropolitain CRDQ, Québec

01097

Dr. med. Beatrice Gerlach, Dresden

D-20246

Universitatsklinikum Hamburg-Eppendorf / IVDP, Hamburg

04103

Universitatsklinikum Leipzig, Leipzig

00144

Istituto Dermatologico San Gallicano IRCCS Dermatologia Clinica, Rome

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY