A Study Comparing GSK2118436 to Dacarbazine (DTIC) in Previously Untreated Subjects With BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) Melanoma

PHASE3CompletedINTERVENTIONAL
Enrollment

251

Participants

Timeline

Start Date

December 23, 2010

Primary Completion Date

December 19, 2011

Study Completion Date

September 16, 2016

Conditions
Cancer
Interventions
DRUG

GSK2118436

150 mg twice daily

DRUG

Dacarbazine (DTIC)

Intravenous (IV), 1000 mg/m2 every 3 weeks until initial progression

Trial Locations (94)

4

GSK Investigational Site, Dublin

7

GSK Investigational Site, Dublin

8

GSK Investigational Site, Dublin

9

GSK Investigational Site, Dublin

2145

GSK Investigational Site, Westmead

3526

GSK Investigational Site, Miskolc

4032

GSK Investigational Site, Debrecen

4215

GSK Investigational Site, Southport

5000

GSK Investigational Site, Adelaide

6009

GSK Investigational Site, Nedlands

7624

GSK Investigational Site, Pécs

10065

GSK Investigational Site, New York

13385

GSK Investigational Site, Marseille

16132

GSK Investigational Site, Genoa

20089

GSK Investigational Site, Rozzano (MI)

24105

GSK Investigational Site, Kiel

28007

GSK Investigational Site, Madrid

28033

GSK Investigational Site, Madrid

28034

GSK Investigational Site, Madrid

28040

GSK Investigational Site, Madrid

28041

GSK Investigational Site, Madrid

28050

GSK Investigational Site, Madrid

30449

GSK Investigational Site, Hanover

31008

GSK Investigational Site, Pamplona

32806

GSK Investigational Site, Orlando

33075

GSK Investigational Site, Bordeaux

33100

GSK Investigational Site, Udine

34125

GSK Investigational Site, Kassel

35128

GSK Investigational Site, Padua

35243

GSK Investigational Site, Birmingham

36608

GSK Investigational Site, Mobile

39120

GSK Investigational Site, Magdeburg

41013

GSK Investigational Site, Seville

41100

GSK Investigational Site, Modena

45122

GSK Investigational Site, Essen

46202

GSK Investigational Site, Indianapolis

48109

GSK Investigational Site, Ann Arbor

48149

GSK Investigational Site, Münster

50937

GSK Investigational Site, Cologne

51092

GSK Investigational Site, Reims

53100

GSK Investigational Site, Siena

53127

GSK Investigational Site, Bonn

55131

GSK Investigational Site, Mainz

56068

GSK Investigational Site, Koblenz

59037

GSK Investigational Site, Lille

65191

GSK Investigational Site, Wiesbaden

66421

GSK Investigational Site, Homburg

67063

GSK Investigational Site, Ludwigshafen am Rhein

69120

GSK Investigational Site, Heidelberg

75006

GSK Investigational Site, Paris

75877

GSK Investigational Site, Paris

89081

GSK Investigational Site, Ulm

90095

GSK Investigational Site, Los Angeles

90419

GSK Investigational Site, Nuremberg

91054

GSK Investigational Site, Erlangen

92093

GSK Investigational Site, La Jolla

93053

GSK Investigational Site, Regensburg

94115

GSK Investigational Site, San Francisco

94589

GSK Investigational Site, Vallejo

94805

GSK Investigational Site, Villejuif

99089

GSK Investigational Site, Erfurt

115478

GSK Investigational Site, Moscow

191104

GSK Investigational Site, Saint Petersburg

197758

GSK Investigational Site, Saint Petersburg

198255

GSK Investigational Site, Saint Petersburg

355047

GSK Investigational Site, Stavropol

390011

GSK Investigational Site, Ryazan

420029

GSK Investigational Site, Kazan'

03756

GSK Investigational Site, Lebanon

T6G 1Z2

GSK Investigational Site, Edmonton

V1Y 5L3

GSK Investigational Site, Kelowna

M4N 3M5

GSK Investigational Site, Toronto

M5G 2M9

GSK Investigational Site, Toronto

H3T 1E2

GSK Investigational Site, Montreal

06202

GSK Investigational Site, Nice

07548

GSK Investigational Site, Gera

07740

GSK Investigational Site, Jena

H-1122

GSK Investigational Site, Budapest

H-9024

GSK Investigational Site, Győr

Unknown

GSK Investigational Site, Cork

Co Galway

GSK Investigational Site, Galway

00144

GSK Investigational Site, Rome

00167

GSK Investigational Site, Rome

05100

GSK Investigational Site, Terni

1066 CX

GSK Investigational Site, Amsterdam

36-200

GSK Investigational Site, Brzozów

62-500

GSK Investigational Site, Konin

31-115

GSK Investigational Site, Krakow

76-200

GSK Investigational Site, Słupsk

02-781

GSK Investigational Site, Warsaw

08916

GSK Investigational Site, Badalona

08035

GSK Investigational Site, Barcelona

08036

GSK Investigational Site, Barcelona

08907

GSK Investigational Site, Hospitalet de Llobregat, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY

NCT01227889 - A Study Comparing GSK2118436 to Dacarbazine (DTIC) in Previously Untreated Subjects With BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) Melanoma | Biotech Hunter | Biotech Hunter