Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

606

Participants

Timeline

Start Date

November 30, 2011

Primary Completion Date

November 30, 2014

Study Completion Date

August 31, 2016

Conditions
Acute Kidney InjuryAbdominal Aortic Aneurysm
Interventions
DRUG

curcumin

Patients will take the study medication (500 mg x 4 capsules, twice daily \[BID\]) for two days leading up to repair, totaling 4000 mg per day. They will take a dose (2000 mg) the morning of repair, at the same time as regular medications not held for surgery. While they are on call to the operating room, they will take another dose of 2000 mg and then another 2000 mg dose 6 hours after the repair. Final dose is administered the morning after repair.

OTHER

placebo

The placebo will look, smell, taste, and in every way be identical to the active drug. Patients will take the study medication in the exact same manner as the curcumin regimen.

Trial Locations (10)

T3B 6A8

University of Calgary, Calgary

T6G 2B7

University of Alberta Hospital, Edmonton

R2H 2A6

St. Boniface Hospital, Winnipeg

P3E5J1

Sudbury Regional Hospital, Greater Sudbury

L8L 2X2

Hamilton General Hospital, Hamilton

N6G 5W9

London Health Sciences Centre, London

K1Y4E9

The Ottawa Hospital, Civic Campus, Ottawa

M4N3M5

Sunnybrook Health Sciences Centre, Toronto

M5B1W8

St. Michael's Hospital, Toronto

H1T 2M4

Maisonneuve-Rosemont Hospital, Montreal

All Listed Sponsors
collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

lead

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

OTHER

NCT01225094 - Curcumin to Prevent Complications After Elective Abdominal Aortic Aneurysm (AAA) Repair | Biotech Hunter | Biotech Hunter