A Phase I Study of AZD1480 in Patients With Advanced Solid Malignancies and Advanced Hepatocellular Carcinoma in the Escalation Phase,Non-Small Cell Lung Cancer(NSCLC) and Non-smokers With Lung Metastasis and Gastric Cancer and Solid Tumour in the Expansion Phase.

PHASE1TerminatedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

November 30, 2010

Primary Completion Date

December 31, 2012

Study Completion Date

December 31, 2012

Conditions
Solid TumourAdvanced Solid MalignanciesChild-Pugh A to B7 Advanced Hepatocellular CarcinomaEGFR and/or ROS Mutant NSCLCLung Metastasis CarcinomaGastric Cancer
Interventions
DRUG

AZD1480 Daily

Oral Dose, Capsule, Daily Dosing

DRUG

AZD1480 BID

Oral Dose, Capsule, BID Dosing

Trial Locations (1)

Unknown

Research Site, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY