Response Prediction in Metastasized Colorectal Cancer Using Intratumoral Thymidylate Synthase

PHASE2CompletedINTERVENTIONAL
Enrollment

168

Participants

Timeline

Start Date

July 31, 2001

Primary Completion Date

June 30, 2010

Study Completion Date

September 30, 2010

Conditions
Colorectal CancerNon Resectable MetastasisReference LesionBiopsyThymidylate Synthase Quantitation
Interventions
DRUG

FUFA

2600/500 mg/m2 i.v. 24 h via port, 1 time weekly for six weeks, than have a break for 2 weeks (=8 weeks for 1 cycle)

DRUG

systemic chemotherapy

CPT-11, 80 mg/m2 for 90 minutes and 5 FU/FA 2000/500 mg/m2 iv. 24h via port; 1 time weekly for six weeks, than have a break for 2 weeks

Trial Locations (1)

Unknown

Department of General, Visceral, and Transplantations Surgery, Univeristy of Ulm, Ulm

All Listed Sponsors
collaborator

Pfizer, Berlin Germany

UNKNOWN

collaborator

Medac, Hamburg, Germany

UNKNOWN

collaborator

Study Group Oncology of Gastrointestinal Tumors (FOGT)

UNKNOWN

lead

University of Ulm

OTHER

NCT01212718 - Response Prediction in Metastasized Colorectal Cancer Using Intratumoral Thymidylate Synthase | Biotech Hunter | Biotech Hunter