Esmolol for Treatment of Perioperative Tachycardia

PHASE3TerminatedINTERVENTIONAL
Enrollment

76

Participants

Timeline

Start Date

September 30, 2010

Primary Completion Date

July 31, 2013

Study Completion Date

July 31, 2013

Conditions
High-risk, Non-cardiovascular Surgeries
Interventions
DRUG

Esmolol

Infusion will be started at 50 mcg/kg/min for 4 minutes and titrated in increments of 50 mcg/kg/min up to a maximum of 300mcg/kg/min (maintenance dose) to maintain a heart rate between 60 and 80 beats per minute (bpm) while maintaining a minimum systolic blood pressure (SBP) of 95 mmHg during the length of surgery and up to 12 hours post-operatively.

Trial Locations (3)

27705

Durham VA Medical Center, Durham

27710

Duke University Medical Center, Durham

43210

Ohio State University, Columbus

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Baxter Healthcare Corporation

INDUSTRY

lead

Duke University

OTHER