28
Participants
Start Date
April 30, 2013
Primary Completion Date
September 30, 2015
Study Completion Date
September 30, 2015
Pioglitazone
A modified dose finding method will be used to determine safety and dose response among three dose levels (0.25mg/kg QD, 0.5mg/kg QD, and 0.75mg/kg QD). The dose has been based on the per weight maximum adult dose. Specifically, the FDA has approved 45mg as the maximum adult dose. For a 60kg adult, this is 0.75mg/kg. There will be 14 weeks of active treatment.
Placebo
There will be a 2 week period of placebo run-in.
Holland Bloorview Kids Rehabilitation Hospital, Toronto
Holland Bloorview Kids Rehabilitation Hospital
OTHER
Evdokia Anagnostou
INDIV