Lapatinib or Trastuzumab Given Prior to Surgery With Chemotherapy in Patients With Early Breast Cancer

Lapatinib 1000 mg orally once daily continuously

Part II (Week 13-24) Trastuzumab 4 mg/kg IV load followed by 2 mg/kg IV Day 1 of each week

Part I (Week 1-12) Epirubicin 90 mg/m2 by IV infusion on Day 1 every 21 days

Part I (Week 1-12) Cyclophosphamide 600 mg/m2 by IV infusion on Day 1 every 21 days

Part II (Week 13-24) Paclitaxel 80 mg/m2 by IV infusion on Day 1 of each week