Preoperative Trial of Sorafenib in Combination With Cisplatin Followed by Paclitaxel for Early Stage Breast Cancer

PHASE2TerminatedINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

June 30, 2010

Primary Completion Date

June 30, 2015

Study Completion Date

June 30, 2015

Conditions
Breast Cancer
Interventions
DRUG

Sorafenib

Sorafenib 400 mg twice daily throughout the study. Patients will receive this as a single-agent for the first four weeks, then in combination with cisplatin followed by paclitaxel.

DRUG

Cisplatin

75 mg/m² given IV

DRUG

Paclitaxel

175 mg/m² given IV

Trial Locations (3)

30303

Grady Memorial Hospital, Atlanta

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Winship Cancer Institute, Atlanta

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Amgen

INDUSTRY

collaborator

Bayer

INDUSTRY

lead

Emory University

OTHER