Compare Pharmaceutical Economics and Efficacy of Sevoflurane With Low Fresh Gas Flow Balanced Anesthesia, Propofol Target Controlled Infusion Anesthesia and Propofol Induction Sevoflurane Maintenance Anesthesia

PHASE4CompletedINTERVENTIONAL
Enrollment

336

Participants

Timeline

Start Date

November 30, 2010

Primary Completion Date

May 31, 2011

Study Completion Date

May 31, 2011

Conditions
Elective Laparoscopic Surgery
Interventions
DRUG

Sevoflurane Inhalational Induction and Maintenance

Sevoflurane was administered at a concentration of 8% via vital capacity induction and sevoflurane 0.8-1.5 minimum alveolar concentration (MAC) with a rate of 1 L/min fresh gas flow for maintenance.

DRUG

Propofol Target Controlled Infusion for Induction and Maintenance

Propofol IV 4 ug/mL was administered with target controlled infusion (TCI) for induction and propofol 3 to 6 ug/mL was administered with TCI for maintenance.

DRUG

Propofol Target Controlled Infusion for Induction and Sevoflurane Inhalation for Maintenance

Propofol was administered as a bolus IV dose of 1.5 mg/kg for induction at a rate of 40 mg/10 seconds. During maintenance, a sevoflurane concentration of 0.8-1.5 minimal alveolar concentration (MAC) was administered at a rate of 1 L/min fresh gas flow.

Trial Locations (4)

100730

Site Reference ID/Investigator# 41983, Beijing

200032

Site Reference ID/Investigator# 41984, Shanghai

510080

Site Reference ID/Investigator# 41985, Guangzhou

Unknown

Site Reference ID/Investigator# 41932, Chengdu

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Rundo International Pharmaceutical Research & Development Co.,Ltd.

INDUSTRY

lead

Abbott

INDUSTRY