A Trial of ZD6474, Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiation Therapy Followed by Surgery

Vandetanib 100mg orally escalating to doses of 200 mg daily 7 days a week until completion of radiation therapy

5-FU 225 mg/m2/day continuous infusion over96 hours during radiation therapy

Carboplatin AUC=5 days 1 and 29 during radiation therapy

Paclitaxel 50 mg/m2 days 1, 8, 15, 22, 29 during radiation therapy

External Beam Radiation Therapy(XRT)to a total dose of 4,500 centiGray (cGy) (180 cGy fractions daily) Monday through Friday for five weeks