Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

226

Participants

Timeline

Start Date

July 20, 2010

Primary Completion Date

November 15, 2016

Study Completion Date

December 9, 2016

Conditions
Multiple MyelomaDiffuse Large B-Cell LymphomaGlioblastoma MultiformeHepatocellular CarcinomaNon-Small Cell Lung CancerNeuroendocrine Tumors of Non-Pancreatic OriginHormone Receptor-Positive Breast Cancer
Interventions
DRUG

CC-223

Part A: (closed to enrollment) Dose level starts with 7.5mg daily taken by mouth in cycles of 28 days. Level increases for different patient cohorts in 100% or 50% increments until optimal dose level is established for further study. Treatment continues for as long as patient benefits (i.e., until disease progression or unacceptable toxicity). Part B: (closed to enrollment) Optimal dose is administered in 28 day cycles until disease progression.

Trial Locations (16)

10016

NYU Cancer Institute - Bellevue Hospital, New York

31052

Institut Claudius Regaud, Toulouse

33612

Moffitt Cancer Center, Tampa

37007

Hospital Universitario de Salamanca, Salamanca

37203

Sarah Cannon Research Institute Drug Development Unit, Nashville

41013

Hospital Universitario Virgen Del Rocio, Seville

55905

Mayo Clinic Cancer Clinical Studies Unit, Rochester

59102

Billings Clinic, Billings

75201

Mary Crowley Medical Research Center, Dallas

90048

Cedars-Sinai Medical Center, Los Angeles

90095

UCLA Neuro-Oncology Program, Los Angeles

94115

University of California, San Francisco Hellen Diller Family Comprehensive Cancer Center, San Francisco

94800

Institut Gustave Roussy Faculte de Medecine Paris Sud Service de pneumologie, Villejuif

07601

Hackensack University Medical Center, Hackensack

W1G 6AD

Sarah Cannon Research Institute UK, London

WC1E 6BT

UCL Cancer Institute, London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Celgene

INDUSTRY