NCT01176032 - ALiskiren or Losartan Effects on bioMARKers of Myocardial Remodeling | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

June 30, 2010

Primary Completion Date

April 30, 2013

Study Completion Date

April 30, 2013

Conditions

HypertensionLeft Ventricle Hypertrophy

Interventions

DRUG

Aliskiren

Aliskiren 300 mg film coated tablets

DRUG

Losartan

Losartan 100 mg tablets

DRUG

Amlodipine

Amlodipine 5mg was given to patients who did not achieve the required blood pressure (\<140/90 mmHg) after 8 weeks (visit 3)of treatment at the maximum doses of study medication in addition to the study medication in order to reach the required BP. at visit 4 (week 18) the dose of amlodipine was increased to 10mg if the required level (\<140/90 mmHg) was still not achieved.

DRUG

Hydrochlorothiazide (HCTZ)

HCTZ 12.5mg was prescribed at visit 5 (week 26) if the required values (\<140/90 mmHg) had not been reached.

Trial Locations (25)

11540

Novartis Investigative Site, Sanlúcar de Barrameda

15706

Novartis Investigative Site, Santiago de Compostela