39
Participants
Start Date
July 31, 2011
Primary Completion Date
March 31, 2014
Study Completion Date
March 31, 2014
Zileuton
600 mg tablets po QID for 5 days prior to endotoxin, stopping 24 hours after endotoxin instillation
Pioglitazone placebo
Lactose filled gelatin capsule, size 00, 1 tablet po bid x 2 weeks prior to endotoxin instillation until 24 hours after endotoxin.
Zileuton placebo
Placebo tablets provided by manufacturer of Zyflo CR (Cornerstone Therapeutics), 2 tablets po bid x 5 days prior to endotoxin instillation until 24 hours after endotoxin.
Pioglitazone
PPAR-gamma agonist
Washington University / Barnes Jewish Hospital, St Louis
Washington University School of Medicine
OTHER
Doris Duke Charitable Foundation
OTHER