Dasatinib With Fludarabine and Rituximab in Relapsed and Refractory CLL and SLL

PHASE2TerminatedINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

July 31, 2010

Primary Completion Date

January 31, 2015

Study Completion Date

January 31, 2015

Conditions
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Interventions
DRUG

dasatinib

Taken orally once a day on days 1-14 of each 28-day cycle

DRUG

Rituximab

Given intravenously, 375 mg/m2 each cycle (dose split, given on Days 3+4 of cycle 1, variable after that).

DRUG

fludarabine

Given intravenously, 25 mg/m2/day, for 3 doses per cycle (Days 3-5 in cycle 1, Days 1-3 after that)

Trial Locations (3)

02114

Massachusetts General Hospital, Boston

02115

Beth Israel Deaconess Medical Center, Boston

Dana-Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Dana-Farber Cancer Institute

OTHER

collaborator

Beth Israel Deaconess Medical Center

OTHER

collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Massachusetts General Hospital

OTHER