Everolimus for Children With NF1 Chemotherapy-Refractory Radiographic Progressive Low Grade Gliomas

PHASE2CompletedINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

July 10, 2010

Primary Completion Date

September 4, 2014

Study Completion Date

October 26, 2017

Conditions
Glioma
Interventions
DRUG

RAD001 (Everolimus)

"If you take part in this research study, you will be given a participant diary for each treatment course to help you keep track of when you take your RAD001. You will be required to bring the completed diary at each scheduled visit. A treatment course lasts 4 weeks and there will not be any breaks between courses. You may stay on study for a total of 12 courses (48 weeks).~You will take the study medication (tablets) by mouth, once a day during each course for as long as you are participating in this study. You will also be required to take an antibiotic during treatment to prevent infection."

Trial Locations (12)

10016

New York University Medical Center, New York

19096

Children's Hospital of Philadelphia, Philadelphia

20010

Children's National Medical Center, Washington D.C.

20892

National Cancer Institute, Bethesda

46202

Indiana University, Indianapolis

60611

Children's Lurie Hospital, Chicago

60637

University of Chicago, Chicago

63110

Washington University, St Louis

84132

University of Utah, Salt Lake City

90027

Children's Hospital Los Angeles, Los Angeles

02115

Children's Hospital Boston, Boston

45229-3039

Cincinnati Children's Hospital Medical Center, Cincinnati

All Listed Sponsors
collaborator

Boston Children's Hospital

OTHER

collaborator

Children's Hospital of Philadelphia

OTHER

collaborator

Children's National Research Institute

OTHER

collaborator

Children's Hospital Medical Center, Cincinnati

OTHER

collaborator

National Cancer Institute (NCI)

NIH

collaborator

University of Chicago

OTHER

collaborator

University of Utah

OTHER

collaborator

Washington University School of Medicine

OTHER

collaborator

Ann & Robert H Lurie Children's Hospital of Chicago

OTHER

collaborator

NYU Langone Health

OTHER

collaborator

Children's Hospital Los Angeles

OTHER

lead

University of Alabama at Birmingham

OTHER