90Y-ibritumomab Tiuxetan Consolidation After 6th R-CHOP Chemotherapy in Patients With Bulky Diffuse Large B Cell Lymphoma

PHASE2CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

January 31, 2007

Primary Completion Date

January 31, 2009

Conditions
Lymphoma, Large B-Cell, Diffuse
Interventions
DRUG

ibritumomab tiuxetan (Zevalin)

During Zevalin treatment, rituximab 250 mg/m2 will be administered with the same methods mentioned above on days 1 and 8. On day 8, within 4 hours following completion of the rituximab dose, 90Y Zevalin at a dose of 0.4 mCi/kg actual body weight for patients with a platelet count \> 150,000/L and 0.3 mCi/kg actual body weight for patients with a platelet count of 100,000 - 149,000/L will be injected intravenously over a period of 10 minutes. The maximum allowable dose of 90Y Zevalin is 32 mCi regardless of the patient's body weight. 90Y Zevalin should be administered within 4 hours after radiolabeling of Zevalin with 90Y.

Trial Locations (1)

519-809

Chonnam National University Hwasun Hospital, Hwasun-gun

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Samsung Medical Center

OTHER

collaborator

Asan Medical Center

OTHER

collaborator

Chonbuk National University Hospital

OTHER

collaborator

Dong-A University Hospital

OTHER

collaborator

Pusan National University Hospital

OTHER

collaborator

Severance Hospital

OTHER

lead

Chonnam National University Hospital

OTHER