Study Evaluating Effect of Esomeprazole, Omeprazole or Lansoprazole on the Pharmacodynamics (PD) and Pharmacokinetics (PK) of Clopidogrel

PHASE1CompletedINTERVENTIONAL

Enrollment

149

Participants

Timeline

Start Date

May 31, 2010

Primary Completion Date

May 31, 2011

Study Completion Date

May 31, 2011

Conditions

Healthy

Interventions

DRUG

lansoprazole

60 mg (2x30-mg capsule), once daily

DRUG

omeprazole

80 mg (2x40-mg capsule), once daily

DRUG

esomeprazole

40 mg (1x40-mg capsule), once daily

DRUG

clopidogrel

300 mg loading dose on Day 1 then 75 mg daily for 28 days

Trial Locations (1)

Research Site, Overland Park