Trial of Three Stem Cell Mobilization Regimens for Multiple Myeloma

PHASE3CompletedINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

March 31, 2011

Primary Completion Date

February 4, 2019

Study Completion Date

February 4, 2019

Conditions
Multiple Myeloma
Interventions
DRUG

bortezomib (Velcade)

1.3 mg/m2 IVP on days 1, 4, 8 and 11

DRUG

cyclophosphamide

2.0 g/m2 (day 4 for Arm A and day 1 for Arm C)

DRUG

G-CSF

given for ten (+/- two) consecutive days starting on day 9 at a dose of 10 micrograms/kg/day (start on day 2 for Arm C and start on Day 1 for Arm D)

DRUG

Plerixafor

plerixafor is given on day 4, approximately 11 hours prior to stem cell collection attempt on Day 5, plerixafor daily until stem cell collection is complete (Arm D), start on Day 12, approximately 11 hours prior to stem cell collection attempt and plerixafor daily until collection if complete (Arm E)

Trial Locations (5)

10016

New York University Cancer Institute, New York

10032

Columbia Presbyterian Medical Center):, New York

10065

Memorial Sloan-Kettering Cancer Center):, New York

Weill Cornell Medical College, New York

30322

Emory University, Atlanta

Sponsors
All Listed Sponsors
collaborator

Millennium Pharmaceuticals, Inc.

INDUSTRY

lead

Weill Medical College of Cornell University

OTHER