70
Participants
Start Date
August 31, 2010
Primary Completion Date
February 28, 2014
Study Completion Date
February 28, 2014
PF-02341066
Arm 1: The starting dose will be 200 mg by mouth, twice a day of PF 02341066 in tablet form The dose of each drug in the combination \[PF-02341066 and PF-00299804\] will be escalated or de-escalated until the maximum tolerated combined dose is reached. Patients will then be treated with the maximum tolerated combined dose.
PF-00299804
Arm 1: The starting dose will be 30 mg by mouth once a day of PF-0029804 in tablet form. The dose of each drug in the combination \[PF-02341066 and PF-00299804\] will be escalated or de-escalated until the maximum tolerated combined dose is reached. Patients will then be treated with the maximum tolerated combined dose.
PF-02341066
Arm 2: With progressive disease the maximum tolerated combined dose of PF-02341066 (given by mouth twice a day in tablet form) and PF-00299804 (given by mouth once a day in tablet form).
PF-00299804
Arm 2: The dose of 45 mg by mouth once a day of PF-00299804 in tablet form until progressive disease and then the maximum tolerated combined dose of PF-02341066 (given by mouth twice a day in tablet form) and PF-00299804 (given by mouth once a day in tablet form).
Peter MacCallum Cancer Centre, Division of Haematology and Medical Oncology, East Melbourne
CCR, National Cancer Institute, Bethesda
Clinical Trials Office University of Colorado Hospital (CTO), Aurora
DRUG SHIPMENT: University of Colorado Cancer Center, Aurora
Rocky Mountain Lions Eye Institute, Aurora
University of Colorado Hospital, Aurora
Drug Shipment Only, Boston
Massachusetts General Hospital, Boston
Brigham & Women's Hospital, Boston
Drug Shipment Only, Boston
Lead Sponsor
Pfizer
INDUSTRY