A Study Of Combined C- MET Inhibitor And PAN-HER Inhibitor (PF-02341066 And PF-00299804) In Patients With Non- Small Cell Lung Cancer

PHASE1CompletedINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

August 31, 2010

Primary Completion Date

February 28, 2014

Study Completion Date

February 28, 2014

Conditions
Non Small Cell Lung Cancer
Interventions
DRUG

PF-02341066

Arm 1: The starting dose will be 200 mg by mouth, twice a day of PF 02341066 in tablet form The dose of each drug in the combination \[PF-02341066 and PF-00299804\] will be escalated or de-escalated until the maximum tolerated combined dose is reached. Patients will then be treated with the maximum tolerated combined dose.

DRUG

PF-00299804

Arm 1: The starting dose will be 30 mg by mouth once a day of PF-0029804 in tablet form. The dose of each drug in the combination \[PF-02341066 and PF-00299804\] will be escalated or de-escalated until the maximum tolerated combined dose is reached. Patients will then be treated with the maximum tolerated combined dose.

DRUG

PF-02341066

Arm 2: With progressive disease the maximum tolerated combined dose of PF-02341066 (given by mouth twice a day in tablet form) and PF-00299804 (given by mouth once a day in tablet form).

DRUG

PF-00299804

Arm 2: The dose of 45 mg by mouth once a day of PF-00299804 in tablet form until progressive disease and then the maximum tolerated combined dose of PF-02341066 (given by mouth twice a day in tablet form) and PF-00299804 (given by mouth once a day in tablet form).

Trial Locations (10)

3002

Peter MacCallum Cancer Centre, Division of Haematology and Medical Oncology, East Melbourne

20892

CCR, National Cancer Institute, Bethesda

80045

Clinical Trials Office University of Colorado Hospital (CTO), Aurora

DRUG SHIPMENT: University of Colorado Cancer Center, Aurora

Rocky Mountain Lions Eye Institute, Aurora

University of Colorado Hospital, Aurora

02114

Drug Shipment Only, Boston

Massachusetts General Hospital, Boston

02115

Brigham & Women's Hospital, Boston

02215

Drug Shipment Only, Boston

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY