Study of 5-azacitidine in Combination With Vorinostat in Patients With Relapsed or Refractory Diffuse Large b Cell Lymphoma (DLBCL)

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

17

Participants

Timeline

Start Date

September 30, 2010

Primary Completion Date

April 30, 2013

Study Completion Date

October 20, 2016

Conditions
Lymphoma
Interventions
DRUG

azacytidine

"* Dose level 1: azacitidine 55 mg/m2 on days 1-5~* Dose level 2: azacitidine 75 mg/m2 on days 1-5~* Dose level 3: azacitidine 55 mg/m2 on days 1-5~* Dose level 4: azacitidine 75 mg/m2 on days 1-5~Each cycle = 28 days. Subjects may receive up to 6 cycles."

DRUG

vorinostat

"* Dose level 1: oral vorinostat at 300 mg BID on Days 1-7.~* Dose level 2: oral vorinostat at 200 mg BID on Days 1-7.~* Dose level 3: oral vorinostat at 300 mg BID on Days 1-14.~* Dose level 4: oral vorinostat at 200 mg BID on Days 1-14.~Each cycle = 28 days. Subjects receive up to 6 cycles."

Trial Locations (1)

10065

Weill Cornell Medical College, New York

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Celgene

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Weill Medical College of Cornell University

OTHER