Phase II Study of Afinitor vs. Sutent in Patients With Metastatic Non-Clear Cell Renal Cell Carcinoma

PHASE2CompletedINTERVENTIONAL
Enrollment

131

Participants

Timeline

Start Date

September 30, 2010

Primary Completion Date

February 28, 2015

Study Completion Date

April 30, 2015

Conditions
Advanced Non-clear Cell Renal Cell Carcinoma
Interventions
DRUG

Everolimus

Subjects in this treatment arm will receive everolimusRAD001 10 mg orally once daily by mouth on days 1 through 42 for each 42 day cycle.

DRUG

Sunitinib

50 mg daily by mouth on days 1 through 28 of each 42 day cycle.

Trial Locations (18)

27708

Duke Univeristy Medical Center, Durham

37203

SCRI, Nashville

37212

The Vanderbilt Clinic, Henry-Joyce Cancer Center, Nashville

44195

Cleveland Clinic, Cleveland

46202

Indiana University Melvin and Bran Simon Cancer Center, Indianapolis

48201

Karmanos Cancer Institute/Wayne State University, Detroit

60637

University of Chicago, Chicago

63110

Washington Univ in St. Louis-School of Medicine, St Louis

97239

Oregon Health & Science University, Portland

V5Z 4E6

BC Cancer Agency, Vancouver

R3E 0V9

CancerCare Manitoba, Med Onc, Dept Hem and Onc, Winnipeg

N6A-4L6

London Health Sciences Center, London

CB2 0QQ

Cambridge Cancer Trials Centre, Cambridge

8W3 6JJ

The Royal Marsden NHS, London

M20 4BX

The Christie Hospital NHS, Manchester

S10 2SJ

Weston Park Hospital, Sheffield

OX3 7LJ

Churchill Hospital, Headington

G12 0YN

Beatson West Scotland Cancer Centre, Glasgow

Sponsors

Lead Sponsor

Collaborators (2)

All Listed Sponsors
collaborator

Novartis

INDUSTRY

collaborator

Pfizer

INDUSTRY

lead

Duke University

OTHER