Effects of cKit Inhibition by Imatinib in Patients With Severe Refractory Asthma (KIA)

PHASE2CompletedINTERVENTIONAL
Enrollment

176

Participants

Timeline

Start Date

November 30, 2010

Primary Completion Date

August 31, 2015

Study Completion Date

August 31, 2016

Conditions
Asthma
Interventions
DRUG

Imatinib mesylate

Imatinib will be initiated at an oral dose of 200 mg (two 100 mg film-coated tables) per day during the first two weeks of treatment. If the treatment is well tolerated, an up-titration to 400 mg daily (four 100 mg film-coated tables) will occur.

DRUG

Placebo

Placebo

Trial Locations (7)

10032

Columbia University, New York

19140

Temple University, Philadelphia

35294

University of Alabama, Birmingham

44195

Cleveland Clinic, Cleveland

53792

University of Wisconsin, Madison

63110

Washington University School of Medicine, St Louis

02115

Brigham and Womens Hospital, Boston

Sponsors
All Listed Sponsors
collaborator

Baim Institute for Clinical Research

OTHER

collaborator

National Heart, Lung, and Blood Institute (NHLBI)

NIH

lead

Brigham and Women's Hospital

OTHER