Reducing Pain and Disability After Breast Cancer Surgery

NACompletedINTERVENTIONAL
Enrollment

129

Participants

Timeline

Start Date

September 30, 2009

Primary Completion Date

September 30, 2012

Study Completion Date

June 30, 2013

Conditions
Breast CancerChronic Pain
Interventions
PROCEDURE

Thoracic Paravertebral Block (TPVB)

The middle of the spinous process above the nerve to be blocked is located and the overlying skin marked 2.5 centimeters lateral to this. Subcutaneous lidocaine is injected and a 22 G Tuohy tipped 8 cm needle is inserted at this level and advanced to identify the transverse process. The needle is then moved caudad off the transverse process and inserted a centimeter into the paravertebral space. Five mls of 0.5% ropivacaine with 1:200,000 epinephrine is injected at each paravertebral space. Blocks adjacent to the C7-T5 spinous processes are performed. For patients randomized to the LA group: The patients are identically positioned, sedated and identical landmarks are used to perform sham paravertebral blocks via a subcutaneous saline injection of 0.5mL with a 25G needle at each level.

PROCEDURE

Local Anesthetic

At the conclusion of surgery, the surgeon will infiltrate the incision with 10 ml of saline 0.9% (TPVB group) or 0.5% ropivacaine (LA group). An axillary drain will be placed. After closure of the wound, 20 ml of saline 0.9% (TPVB group) or 0.5% ropivacaine (LA group) will be injected through the drain and the drain clamped for 30 minutes after injection.

Trial Locations (1)

K1Y 4E9

The Ottawa Hospital, Ottawa

All Listed Sponsors
collaborator

Canadian Breast Cancer Foundation

OTHER

lead

Ottawa Hospital Research Institute

OTHER