366
Participants
Start Date
March 31, 2010
Primary Completion Date
February 28, 2013
Study Completion Date
May 31, 2013
lamivudine
patients in this arm will receive oral lamivudine 100mg,daily for 24 weeks; if patients with HBV DNA higher than 1000 copies/ml at week 24, add on adefovir to week 104; otherwise, keep lamivudine monotherapy to week 104
lamivudine
Patients will receive oral lamivudine 100mg,daily for 104 weeks, if HBV DNA breakthrough, add on oral adefovir 10mg daily
lamivudine, adefovir
patients in this arm will receive oral lamivudine 100mg daily and adefovir 10mg for 104 weeks
Beijing Ditan Hospita, Beijing
Beijing Friendship Hospital Attached to the Capital Medical University, Beijing
BeiJing YouAn Hospital ,Capital Medical University, Beijing
Department of infectious disease, First Hospital of Peking University, Beijing
People'S Hospital Under Beijnig University, Beijing
The Second Affiliated of ChongQing University of Medical Science, Chongqing
The First Affiliated Hospital of Fujian Medical University, Fuzhou
The First People's Hospital of Foshan, Foshan
Department of infectious disease, Nanfang Hospital, Guangzhou
GuangDong Provincial People's hospital, Guangzhou
First Affiliated Hospital of Guangxi Medical University, Nanning
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology, Wuhan
Xiangya Hospital Central-South Univrsity, Changsha
First Hospital .Jilin Unniversity, Changchun
ShengJing Hospital of China Medical University, Shenyang
JiNan Infectious Diseases Hospital, Jinan
Changhai Hospital affiliated to Second Military Medical University, Shanghai
Huashan Hospital，Fudan University, Shanghai
No.85 Hospital of PLA, Shanghai
Shanghai Ruijin Hospital, Shanghai
Tangdu Hospital, XiAn
West China Hospital.SiChuan University, Chengdu
HangZhou No.6 People Hospital, Hangzhou
The First Affiliated Hospital of College of Medicine ，Zhejiang University, Hangzhou
Collaborators (1)
Major Science and Technology Special Project of China Eleventh Five-year
OTHER
GlaxoSmithKline
INDUSTRY
Nanfang Hospital, Southern Medical University
OTHER