Study of Sunitinib in Subjects With High Risk Renal Cell Carcinoma

50mg/day for 4 weeks

Conducted prior to administration of sunitinib therapy

Nephrectomy 2-4 weeks after last dose of Sunitinib

"Biomarker evaluation of blood prior to treatment, after 4 weeks of Sunitinib administration, and every three months for a year after surgery.~Biomarker evaluation of tissue prior to 4 week administration of Sunitinib"