A Study to Test the Effects of Riociguat in Patients With Pulmonary Hypertension Associated With Left Ventricular Systolic Dysfunction

PHASE2CompletedINTERVENTIONAL
Enrollment

202

Participants

Timeline

Start Date

April 14, 2010

Primary Completion Date

June 6, 2012

Study Completion Date

July 23, 2025

Conditions
Hypertension, PulmonaryVentricular Dysfunction, Left
Interventions
DRUG

Riociguat (Adempas, BAY63-2521)

up to 2 mg three times a day (increasing from 0.5 to 1 to 2 mg)

DRUG

Riociguat (Adempas, BAY63-2521)

up to 1 mg three times a day (increasing from 0.5 to 1 mg)

DRUG

Riociguat (Adempas, BAY63-2521)

fixed 0.5 mg three times a day

DRUG

Placebo

Placebo three times a day

Trial Locations (83)

1070

Brussels

1090

Vienna

1205

Geneva

2010

Sydney

3000

Leuven

3004

Melbourne

4029

Herston

6020

Innsbruck

6900

Lugano

7198

Palma

8091

Zurich

8200

Aarhus N

9000

Ghent

9300

Aalst

12808

Prague

15006

A Coruña

17475

Greifswald

21201

Baltimore

22042

Falls Church

27100

Pavia

28041

Madrid

28222

Majadahonda

30120

Murcia

31059

Toulouse

33136

Miami

33604

Pessac

44035

Nantes

45014

Fairfield

45219

Cincinnati

46026

Valencia

50937

Cologne

52242

Iowa City

53215

Milwaukee

55905

Rochester

59037

Lille

63110

St Louis

69115

Heidelberg

69677

Bron

76031

Rouen

77900

Olomouc

80131

Naples

86156

Augsburg

90502

Torrance

92103

San Diego

92683

Westminster

99089

Erfurt

100020

Beijing

119074

Singapore

169609

Singapore

200032

Shanghai

200433

Shanghai

308433

Singapore

90073-1003

Los Angeles

02114-2696

Boston

T6G 2B7

Edmonton

V5Z 1M9

Vancouver

H3T 1E2

Montreal

G1V 4G5

Québec

656 91

Brno

140 21

Prague

466-8560

Nagoya

489-8642

Seto

503-8502

Ōgaki

311-3193

Higashiibaraki

514-1101

Tsu

980-8574

Sendai

530-8480

Kita-ku, Osaka

541-8567

Osaka

565-0871

Suita

525-8585

Kusatsu

411-8611

Sunto

116-8567

Arakawa-ku

162-8666

Shinjuku-ku

646-8558

Tanabe

1081 HV

Amsterdam

1091 AC

Amsterdam

6525 GA

Nijmegen

85-168

Bydgoszcz

80-214

Gdansk

04-628

Warsaw

08003

Barcelona

CB2 0AY

Cambridge

SW3 6NP

London

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Bayer

INDUSTRY