21
Participants
Start Date
February 28, 2010
Primary Completion Date
October 31, 2014
Study Completion Date
May 31, 2015
DFMO
"Escalating doses of DFMO in a 3 +3 cohort design.~DFMO at current cohort Dose Level orally each day for 21 day cycles~Dose level 1: 500 mg/m2 PO BID Dose level 2: 750 mg/m2 PO BID Dose level 3:1000 mg/m2 PO BID Dose level 4:1500 mg/m2 PO BID"
Etoposide
Starting with Cycle 2, etoposide will be given at 50mg/m2/dose PO daily for the first 14 days of each 21 day cycle. Capsules will be rounded to closest 50 mg.
Levine Children's Hospital, Charlotte
Arnold Palmer Hospital for Children- MD Anderson, Orlando
Helen DeVos Children's Hospital, Grand Rapids
Children's Mercy Hospitals and Clinics, Kansas City
Children's Hospital of Orange County, Orange
Connecticut Children's Hospital, Hartford
UVM/FAHC, Burlington
Collaborators (1)
Cancer Prevention Pharmaceuticals, Inc.
INDUSTRY
University of Arizona
OTHER
University of Hawaii
OTHER
Giselle Sholler
OTHER