UMPIRE - Use of a Multidrug Pill In Reducing Cardiovascular Events

PHASE3CompletedINTERVENTIONAL
Enrollment

2,004

Participants

Timeline

Start Date

June 30, 2010

Primary Completion Date

July 31, 2012

Study Completion Date

September 30, 2012

Conditions
Cardiovascular Diseases
Interventions
DRUG

polypill

"The polypill will be taken once/day in the form of a hard capsule, to be taken orally. There are two versions of the polypill (Red Heart Pill):~Version 1 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Atenolol 50mg; Version 2 contains aspirin 75mg, simvastatin 40mg, Lisinopril 10mg and Hydrochlorothiazide 12.5mg."

DRUG

Usual cardiovascular medications

Participants in the 'Usual Care' arm will continue to take the separate, individual medications prescribed by their usual doctor, e.g. aspirin, blood pressure lowering drugs, statins.

Trial Locations (7)

2050

George Institute Australia, Sydney

110016

Centre for Chronic Disease Control, New Delhi

110049

Public Health Foundation of India, New Dehli

500033

George Institute for International Health - India, Hyderabad

Dublin 9

Royal College of Surgeons in Ireland Research Institute, Dublin

3584 CX

University Medical Center Utrecht, Utrecht

W2 1LA

Clinical Investigation Unit, International Centre for Circulatory Health, Imperial College London, Paddington

Sponsors
All Listed Sponsors
collaborator

European Commission

OTHER

collaborator

Imperial College Healthcare NHS Trust

OTHER

collaborator

Royal College of Surgeons, Ireland

OTHER

collaborator

UMC Utrecht

OTHER

collaborator

The George Institute

OTHER

collaborator

Public Health Foundation of India

OTHER

collaborator

Dr. Reddy's Laboratories Limited

INDUSTRY

lead

Imperial College London

OTHER