CS1008- in Combination With Sorafenib Compared to Sorafenib Alone in Subjects With Advanced Liver Cancer

PHASE2CompletedINTERVENTIONAL
Enrollment

172

Participants

Timeline

Start Date

July 9, 2010

Primary Completion Date

July 13, 2012

Study Completion Date

September 9, 2013

Conditions
Advanced Hepatocellular CarcinomaLiver CancerHepatic CancerLiver Neoplasms
Interventions
DRUG

CS-1008 2 mg/kg

On a once a week basis CS-1008 will be administered intravenously starting at 2 mg/kg.

DRUG

Sorafenib

On a daily basis, one sorafenib tablet, 400 mg, is taken orally twice a day. The total daily dose of sorafenib is 800 mg. The sorafenib tablets are taken at least 1 hour before or 2 hours after a meal.

DRUG

CS-1008 6/2 mg/kg

A 6 mg/kg loading dose of CS-1008 will be administered intravenously, followed by a 2 mg/kg/week maintenance dose on a once-a-week basis.

DRUG

CS-1008 6/6 mg/kg

A 6 mg/kg loading dose of CS-1008 will be administered intravenously, followed by a 6 mg/kg/week maintenance dose on a once-a-week basis.

DRUG

CS-1008 4 mg/kg

On a once a week basis CS-1008 will be administered intravenously at 4 mg/kg if tolerated.

DRUG

CS-1008 6 mg/kg

On a once a week basis CS-1008 will be administered intravenously at 6 mg/kg if tolerated.

Trial Locations (28)

500

Changhua Christian Hospital, Changhua

704

National Cheng-Kung University Hospital, Tainan City

807

Kaohslung Medical University Hospital, Kaohsiung City

10029

The Mount Sinai Medical Center, New York

20007

Georgetown-Lombardi Cancer Center, Washington D.C.

33305

Chang Gung Medical Foundation-Linkuo, Taoyuan District

37232

Vanderbilt-Ingram Cancer Center, Nashville

73657

Chi-Mei Medical Center, Tainan City

90057

Kenmar Research Group, Los Angeles

830-0011

Kurume University Hospital, Kurume-shi

Unknown

Hiroshima University, Hiroshima

Kanazawa University, Kanazawa

Yamaguchi University Hospital, Ube

Kaohiung Chang Gung Hospital, Kaohsiung City

Chang Gung Memorial Hospital, Chiayi City

National Taiwan University Hospital, Taipei

589-8511

Kinki University Hospital, Osaka

260-8677

Chiba University Hospital, Chiba

700-8558

Okayama University Hospital, Okayama

537-8511

Osaka Med Center Cancer and Cardiovascular Disease, Osaka

180-8610

Musashino Red-Cross Hospital, Tokyo

700-712

Keimyung University Dongsan Hospital, Daegu

110-744

Seoul National University Hospital, Seoul

120-752

Severance Hospital, Seoul

135-710

Samsung Medical Center, Seoul

136-705

Korea University Anam Hospital, Seoul

137-701

Catholic Univ. of Korea, Seoul St. Mary's Hospital, Seoul

138-736

Asan Medical Center, Seoul

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Daiichi Sankyo

INDUSTRY