Chemotherapy Plus Cetuximab Followed by Surgical Resection in Patients With Locally Advanced or Recurrent Thymoma or Thymic Carcinoma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

December 31, 2009

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
ThymomaThymic CarcinomaClinical Masaoka Stage II to IVA
Interventions
DRUG

Cetuximab, Cisplatin, Doxorubicin & Cyclophosphamide

Patients will receive single agent cetuximab infusion starting with a 400mg/m2 IV loading dose on day 1 of week 1, followed by weekly infusions (250mg/m2) on day 1 of weeks 2 3, and 4. Patients will receive single agent cetuximab infusion starting with a 400mg/m2 IV loading dose on day 1 of week 1, followed by weekly infusions (250mg/m2) on day 1 of weeks 2 3, and 4. Patients who have completed the neo-adjuvant treatment regimen, who have no evidence of distant progression, and who are medically operable will proceed to surgical resection within 6 weeks of the last infusion.

Trial Locations (8)

10065

Memorial Sloan Kettering Cancer Center, New York

10591

Memorial Sloan Kettering Cancer Center at Phelps Memorial Hospital Center, Sleepy Hollow

10604

Memorial Sloan Kettering West Harrison, Harrison

11725

Memorial Sloan Kettering Cancer Center @ Suffolk, Commack

77030

Md Anderson Cancer Center, Houston

91010-3000

City of Hope Medical Center, Duarte

07920

Memorial Sloan Kettering at Basking Ridge, Basking Ridge

Unknown

Memorial Sloan Kettering at Mercy Medical Center, Rockville Centre

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

collaborator

M.D. Anderson Cancer Center

OTHER

collaborator

City of Hope National Medical Center

OTHER

lead

Memorial Sloan Kettering Cancer Center

OTHER