Everolimus (RAD001) for the Treatment of Malignant Pleural Mesothelioma With Merlin/NF2 Loss as a Biomarker to Predict Sensitivity

PHASE2CompletedINTERVENTIONAL
Enrollment

11

Participants

Timeline

Start Date

December 31, 2009

Primary Completion Date

July 31, 2012

Study Completion Date

July 31, 2012

Conditions
Malignant Pleural Mesothelioma
Interventions
DRUG

everolimus

Everolimus will be administered at a dose of 10mg orally once daily continuously. Dose reduction may be required depending on the type and severity of toxicity encountered. One cycle will be considered 28 days. Patients will have CT scans to evaluate for response after cycle 1 and cycle 2, and then every two cycles thereafter.

Trial Locations (3)

10065

Memorial Sloan Kettering Cancer Center, New York

02115

Dana Farber Cancer Institute, Boston

19104-4283

University of Pennsylvania, Philadelphia

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

collaborator

Dana-Farber Cancer Institute

OTHER

collaborator

University of Pennsylvania

OTHER

lead

Memorial Sloan Kettering Cancer Center

OTHER