Non-dependent Lung High Frequency Positive Pressure Ventilation (HFPPV) and Right Ventricular Function

PHASE1CompletedINTERVENTIONAL
Enrollment

33

Participants

Timeline

Start Date

February 29, 2004

Primary Completion Date

December 31, 2006

Study Completion Date

February 28, 2007

Conditions
Lung DiseasesEsophageal Diseases
Interventions
PROCEDURE

conventional OLV followed with IL-HFPPV

The patients' lungs were mechanically ventilated with intermittent positive pressure ventilation using fraction of inspired oxygen (FiO2) of 0.5 in air, tidal volume (VT) of 8 mL/kg, inspiratory to expiratory \[I: E\] ratio of 1:2.5, zero positive end-expiratory pressure (PEEP), respiratory rate (R.R) was adjusted to achieve an arterial carbon dioxide tension (PaCO2) 35-45 mm Hg and peak inspiratory pressures were limited to 35 cm H2O. After pleurotomy, OLV was initiated with the same ventilatory settings for the dependent lung. After 30 min, the non-dependent collapsed lung was ventilated using HFPPV mode (IL-HFPPV) with another identical ventilator, with an internal circuit of low compliance, using FiO2 of 0.5 in air, VT 3 mL/kg, I: E ratio \<0.3 and R.R 60 breaths/min.

Trial Locations (1)

Unknown

Cardiothoracic Unit, Faculty of Medicine, Mansoura University, Egypt, Al Mansurah

All Listed Sponsors
collaborator

Mansoura University

OTHER

lead

King Faisal University

OTHER

NCT01019993 - Non-dependent Lung High Frequency Positive Pressure Ventilation (HFPPV) and Right Ventricular Function | Biotech Hunter | Biotech Hunter