Therapeutic Intensification Plus Immunomodulation in HIV-infected Patients

PHASE2CompletedINTERVENTIONAL
Enrollment

29

Participants

Timeline

Start Date

September 30, 2010

Primary Completion Date

July 31, 2012

Study Completion Date

February 28, 2013

Conditions
HIV-1 Infection
Interventions
DRUG

ART Intensification

Current ART regimen plus raltegravir and maraviroc Raltegravir : 400 mg PO BID for 56 weeks Maraviroc : 150, 300 or 600 mg PO BID depending on concomitant ART treatment, for 56 weeks

BIOLOGICAL

Immunomodulation

Starting at Week 8, 1 cycle of 3 injections (1 per week) of recombinant human Interleukin-7 (r-hIL-7 / CYT107) at a 20 µg/kg dose.

Trial Locations (5)

20127

San Raffaele Scientific Institute, Milan

75013

Groupe Hospitalier Pitié-Salpêtrière, Paris

08916

Fundacio Irsicaixa, Badalona

08036

University Hospital Clinic of Barcelona, Barcelona

NW3 2QG

Royal Free Hospital, London

Sponsors

Collaborators (2)

All Listed Sponsors
collaborator

Cytheris SA

INDUSTRY

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

collaborator

Pfizer

INDUSTRY

lead

Objectif Recherche Vaccins SIDA

OTHER

NCT01019551 - Therapeutic Intensification Plus Immunomodulation in HIV-infected Patients | Biotech Hunter | Biotech Hunter