Radiation Therapy and Temsirolimus or Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma

PHASE2CompletedINTERVENTIONAL
Enrollment

111

Participants

Timeline

Start Date

October 31, 2009

Primary Completion Date

December 31, 2013

Study Completion Date

March 31, 2014

Conditions
Brain and Central Nervous System Tumors
Interventions
DRUG

temozolomide

TMZ will be given at 75 mg/m2 daily for the whole period of RT including weekends as registered.

DRUG

temsirolimus

CCI-779 will be given i.v. once every week at 25 mg. Each treatment should be preceded by supportive medication with a histamine H2-receptor antagonist. A first dose of CCI-779, being 25 mg, will be given on day -7 from RT start.

Trial Locations (13)

44805

Institut de Cancerologie de l'Ouest (ICO) - Centre Rene Gauducheau, Nantes-Saint Herblain

Unknown

UZ Leuven, Leuven

Ospedale Regionale Bellinzona e Valli, Bellinzona

Clatterbridge Cancer Centre NHS Foundation Trust, Bebington

Western General Hospital, Edinburgh

FR 75651

CHU Pitie-Salpetriere AP-HP, Paris

DE 79106

Universitaetsklinikum Freiburg, Freiburg im Breisgau

D-69120

Universitatsklinikum Heidelberg, Heidelberg

I-40139

Ospedale Bellaria, Bologna

NL 3008

Erasmus MC - Daniel den Hoed Cancer Center, Rotterdam

NL 2501

Medisch Centrum Haaglanden - Westeinde, The Hague

ES 08916

ICO Badalona - Hospital Germans Trias i Pujol, Badalona

CH-8091

UniversitaetsSpital Zuerich, Zurich

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

NCT01019434 - Radiation Therapy and Temsirolimus or Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma | Biotech Hunter | Biotech Hunter